Description

Ethyl 1-Ribofuranosyl-1,2,4-Triazole-3-Carboximidate is a specialized nucleoside analogue building block of significant interest in advanced pharmaceutical research and development. This compound serves as a crucial synthetic intermediate for the creation of novel antiviral and anticancer agents, particularly those targeting RNA-based mechanisms. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of modified nucleosides and nucleotide prodrugs.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of ribavirin analogues and other broad-spectrum antiviral nucleosides.
• Antiviral Drug Discovery: Building block for developing potential therapeutics against RNA viruses, including hepatitis C (HCV) and respiratory syncytial virus (RSV).
• Oncology Research: Used in the design and synthesis of nucleoside-based chemotherapeutic agents and targeted cancer therapies.
• Prodrug Synthesis: Intermediate for creating prodrug forms of nucleoside analogues to enhance bioavailability and therapeutic efficacy.
• Biochemical Research: Tool compound for studying enzyme inhibition, particularly viral polymerases and cellular kinases.
• Fine Chemical Synthesis: Valuable chiral synthon for constructing complex heterocyclic molecules in medicinal chemistry.

Basic Information

Product Name	Ethyl 1-Ribofuranosyl-1,2,4-Triazole-3-Carboximidate
CAS No.	120362-26-7
Molecular Formula	C10H14N4O5
Molecular Weight	270.24 g/mol
Synonyms	1-(β-D-Ribofuranosyl)-1,2,4-triazole-3-carboximidic Acid Ethyl Ester; Ethyl 1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboximidate; 1-(β-D-Ribofuranosyl)-1H-1,2,4-triazole-3-carboximidic Acid Ethyl Ester; Ribavirin Impurity; Ribavirin Intermediate; 1,2,4-Triazole-3-carboximidic acid, 1-(β-D-ribofuranosyl)-, ethyl ester; ETCA
EINECS	Contact for details

Quality Control

Our Ethyl 1-Ribofuranosyl-1,2,4-Triazole-3-Carboximidate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with ICH guidelines for impurities and can provide material meeting specific customer requirements for advanced synthetic work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) in a desiccator.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.