Description

[47-Lysine]Hirudin (Hv2), Leech is a highly specific and potent recombinant thrombin inhibitor derived from the medicinal leech. This compound is critical for advanced biochemical research and therapeutic development due to its precise anticoagulant mechanism. It is primarily utilized by pharmaceutical R&D teams, diagnostic manufacturers, and academic institutions focused on cardiovascular and hematological studies.

Application

• Anticoagulant Research: As a standard and specific inhibitor for studying thrombin activity, blood coagulation cascades, and platelet aggregation mechanisms.
• Therapeutic Development: Serves as a key reference compound and potential building block for developing novel antithrombotic and antiplatelet drugs.
• Diagnostic Reagents: Used in the formulation of specialized in-vitro diagnostic kits and assays for measuring thrombin levels or assessing clotting function.
• Biochemical Tool: Essential for enzyme kinetics studies, protein-protein interaction analysis, and structure-activity relationship (SAR) research involving serine proteases.
• Standard Reference Material: Employed for quality control and calibration in pharmaceutical manufacturing processes involving anticoagulant products.

Basic Information

Product Name	[47-Lysine]Hirudin (Hv2), Leech
CAS No.	120300-65-4
Molecular Formula	C181H273N49O55S6
Molecular Weight	Approx. 4293.8 g/mol
Synonyms	Hirudin Variant 2; Lys-47-Hirudin; Recombinant Hirudin (Hv2); r-Hirudin; HV2; Thrombin Inhibitor (Hirudin); Leech-derived Anticoagulant Peptide; Antithrombin Hirudin; Hirudin (47-Lys); Hirudin Fragment; Ecarin Clotting Time (ECT) Reference Standard
EINECS	Contact for details

Quality Control

Our [47-Lysine]Hirudin (Hv2) is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, potency, and identity. We adhere to relevant quality management systems to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Potency (Thrombin Inhibition Assay)	≥ 12,000 ATU/mg
Water Content (Karl Fischer)	≤ 5.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.