Description

6,6,6-Trifluoronorleucine is a high-value, non-proteinogenic amino acid derivative characterized by the strategic incorporation of fluorine atoms. This fluorinated building block is essential for modulating the physicochemical and metabolic properties of peptides and small molecules in advanced research and development. It is primarily utilized by pharmaceutical and agrochemical R&D teams for structure-activity relationship (SAR) studies, medicinal chemistry, and the development of novel bioactive compounds.

Application

• Medicinal Chemistry & Drug Discovery: A key fluorinated synthon for creating analogs to enhance metabolic stability, lipophilicity, and binding affinity in lead optimization.
• Peptide Engineering: Used to incorporate fluorinated amino acids into peptides to study conformation, improve proteolytic resistance, and develop novel peptide therapeutics.
• Biochemical Research: Serves as a tool compound in enzyme inhibition studies and metabolic pathway investigations due to its isosteric properties.
• Agrochemical Development: Employed in the synthesis of novel fluorinated active ingredients for crop protection products.
• Positron Emission Tomography (PET) Tracer Precursor: Potential use as a building block for F-18 labeled radiopharmaceuticals for diagnostic imaging.
• Material Science: Exploration in the synthesis of specialized fluorinated polymers and surface modifiers.

Basic Information

Product Name	6,6,6-Trifluoronorleucine
CAS No.	120200-04-6
Molecular Formula	C6H10F3NO2
Molecular Weight	185.14 g/mol
Synonyms	6,6,6-Trifluoronorleucine; (S)-2-Amino-6,6,6-trifluorohexanoic acid; L-6,6,6-Trifluoronorleucine; 6,6,6-Trifluoro-L-norleucine; 2-Amino-6,6,6-trifluorohexanoic acid; Norleucine, 6,6,6-trifluoro-; (2S)-2-Amino-6,6,6-trifluorohexanoic acid
EINECS	Contact for details

Quality Control

Our 6,6,6-Trifluoronorleucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.