Description

4-Amino-2,5-Difluorophenol is a versatile fluorinated aromatic building block characterized by its amino and phenolic functional groups. This compound is crucial for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique substitution pattern enables precise molecular design. It is primarily sought after by R&D chemists and process development teams in the life sciences and specialty chemical sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, leveraging the fluorine atoms for enhanced bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes.
• Polymer Modification: Employed to introduce fluorine and reactive phenolic groups into polymer chains, altering thermal and chemical resistance properties.
• Dye & Pigment Intermediate: Utilized in the production of specialized fluorinated dyes and pigments for high-performance applications.
• Cross-coupling Reactions: Acts as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to create complex biaryl structures.

Basic Information

Product Name	4-Amino-2,5-Difluorophenol
CAS No.	120103-19-7
Molecular Formula	C6H5F2NO
Molecular Weight	145.11 g/mol
Synonyms	2,5-Difluoro-4-aminophenol; 4-Amino-2,5-difluorophenol; 4-Hydroxy-3,6-difluoroaniline; 3,6-Difluoro-4-hydroxyaniline; 2,5-Difluoro-4-hydroxyaniline; Phenol, 4-amino-2,5-difluoro-; Aniline, 3,6-difluoro-4-hydroxy-
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-2,5-Difluorophenol is manufactured under a strict quality management system. We provide comprehensive analytical documentation to ensure traceability and compliance with your project requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Single impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.