Description

2-Acetamido-4,4,4-trifluorobutanoic Acid is a high-value fluorinated amino acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique trifluoromethyl group imparts desirable properties such as enhanced metabolic stability and lipophilicity, making it indispensable for modern pharmaceutical research and development. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated peptides, protease inhibitors, and other active pharmaceutical ingredients (APIs) targeting metabolic and neurological diseases.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, where the trifluoromethyl group can improve compound activity and environmental persistence.
• Fluorine Chemistry & Material Science: Acts as a versatile precursor for introducing fluorine atoms into complex organic frameworks for advanced materials with tailored properties.
• Bioconjugation & Probe Development: Useful in modifying biomolecules or creating fluorescent or radioactive probes for biochemical and diagnostic applications.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in asymmetric synthesis and fluorine chemistry.

Basic Information

Product Name	2-Acetamido-4,4,4-trifluorobutanoic Acid
CAS No.	120097-65-6
Molecular Formula	C6H8F3NO3
Molecular Weight	199.13 g/mol
Synonyms	N-Acetyl-4,4,4-trifluoro-DL-norvaline; 4,4,4-Trifluoro-2-acetamidobutanoic Acid; 2-Acetylamino-4,4,4-trifluorobutanoic Acid; 2-(Acetylamino)-4,4,4-trifluorobutanoic Acid; N-Acetyl-4,4,4-trifluoronorvaline; 2-Acetamido-4,4,4-trifluorobutyric Acid; (RS)-2-Acetamido-4,4,4-trifluorobutanoic Acid; DL-2-Acetamido-4,4,4-trifluorobutanoic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-Acetamido-4,4,4-trifluorobutanoic Acid is manufactured under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles. Our quality protocols are designed to support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Optical Purity (Chiral HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.