Description

Thyrotropin-Releasing Hormone, 1-(Methano-Glp(2,3))- is a synthetic, stabilized analog of the endogenous thyrotropin-releasing hormone (TRH). This modification enhances its metabolic stability and receptor binding affinity, making it a critical tool for advanced endocrinology research and diagnostic development. It is primarily utilized by pharmaceutical R&D teams, clinical research organizations, and manufacturers of in-vitro diagnostic assays. The compound is supplied to exacting standards to ensure reliable and reproducible results in sensitive biological applications.

Application

• Endocrinology Research: Used as a reference standard and active agent in studies of the hypothalamic-pituitary-thyroid (HPT) axis, hormone release mechanisms, and receptor-ligand interactions.
• Diagnostic Kit Manufacturing: Serves as a key calibrant or component in immunoassays and other in-vitro diagnostic (IVD) tests designed to measure thyroid-stimulating hormone (TSH) or assess pituitary function.
• Pharmaceutical Development: Employed in preclinical studies for the development of novel therapeutics targeting neuroendocrine disorders and metabolic diseases.
• Biochemical Standardization: Acts as a high-purity standard for the qualification and validation of analytical methods, including HPLC and mass spectrometry, in quality control laboratories.
• Neuroscience Studies: Investigated for its potential neuromodulatory and neuroprotective effects beyond its classic endocrine functions.

Basic Information

Product Name	Thyrotropin-Releasing Hormone, 1-(Methano-Glp(2,3))-
CAS No.	120083-46-7
Molecular Formula	C16H22N6O4
Molecular Weight	362.38 g/mol
Synonyms	1-(Methano-Glp(2,3))-TRH; TRH Analog; Stabilized TRH; (3S,6S)-3-[[(2S)-1-[[(2S)-1-[[(2S)-2-[[(2S)-2-Acetamidopropanoyl]amino]propanoyl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-6-(5-oxo-2,5-dihydro-1H-pyrrol-3-yl)-2,5-diketopiperazine; Cyclo(Glp-His-Pro-NH2) analog; Methano-bridged TRH; Pyroglutamyl-histidyl-prolinamide analog
EINECS	Contact for details

Quality Control

Our Thyrotropin-Releasing Hormone, 1-(Methano-Glp(2,3))- is manufactured under controlled conditions to ensure the highest standards of purity and consistency. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and specific tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or CoA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.