Description

n-Fmoc-N'-(4-Methoxy-2,3,6-Trimethylbenzenesulfonyl)-D-Arginine is a sophisticated, orthogonally protected derivative of D-arginine, designed for advanced peptide synthesis. This compound matters because it provides critical selectivity in solid-phase peptide synthesis (SPPS), allowing for the precise, sequential assembly of complex peptides and proteins. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid derivative for the Fmoc/tBu strategy, enabling the controlled incorporation of D-arginine.
• Pharmaceutical R&D: Synthesis of novel peptide drug candidates, including antimicrobial peptides, hormone analogs, and targeted cancer therapies.
• Bioconjugation: Used in the preparation of peptide-protein or peptide-small molecule conjugates for drug delivery systems.
• Chemical Biology Probes: Building block for creating labeled or modified peptides used in studying protein-protein interactions and enzyme mechanisms.
• Process Development: Scaling up the production of specific peptide sequences for clinical and commercial manufacturing.
• Academic Research: Fundamental studies in peptide chemistry, stereochemistry, and the development of new synthetic methodologies.

Basic Information

Item	Detail
Product Name	n-Fmoc-N'-(4-Methoxy-2,3,6-Trimethylbenzenesulfonyl)-D-Arginine
CAS No.	120075-24-3
Molecular Formula	C32H38N4O7S
Molecular Weight	622.73 g/mol
Synonyms	Fmoc-D-Arg(Mtr)-OH; N-α-Fmoc-N-ω-(2,3,6-trimethyl-4-methoxybenzenesulfonyl)-D-arginine; Fmoc-D-Arg(Mtr)-OH; D-Arg(Mtr)-Fmoc; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N'-[4-methoxy-2,3,6-trimethylphenyl)sulfonyl]-D-arginine; Fmoc-D-Arginine(Mtr)-OH; (2R)-5-[[(4-Methoxy-2,3,6-trimethylphenyl)sulfonyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid
EINECS	Contact for details

Quality Control

Our n-Fmoc-N'-(4-Methoxy-2,3,6-Trimethylbenzenesulfonyl)-D-Arginine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. We provide Certificates of Analysis (COA) with detailed specifications, ensuring the material meets the stringent requirements for pharmaceutical R&D and cGMP-guided production. Our commitment to traceability and consistency guarantees reliable performance in your most critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere (argon or nitrogen) after each use to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.