Description

Sarafotoxin S6A1 is a potent and highly selective endothelin receptor agonist, a class of peptides originally derived from snake venom. This compound is a critical research tool for studying the endothelin system, which plays a key role in cardiovascular regulation, vasoconstriction, and cell proliferation. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular disease research, receptor pharmacology studies, and the development of novel therapeutic agents targeting endothelin pathways.

Application

• Pharmacological Research: Used as a standard agonist in in vitro and in vivo studies to investigate endothelin receptor (ETA and ETB) function and signaling pathways.
• Cardiovascular Disease Modeling: Essential for creating experimental models of hypertension, vasospasm, and heart failure to evaluate potential drug candidates.
• Receptor Binding Assays: Serves as a high-affinity ligand in competitive binding studies to screen for new endothelin receptor antagonists.
• Cell Signaling Studies: Applied in cellular assays to examine the effects of endothelin receptor activation on second messengers like calcium mobilization and IP3 production.
• Academic & Educational Use: A key reference standard in university laboratories for teaching advanced concepts in peptide pharmacology and cardiovascular physiology.
• Biotech & Pharma R&D: Supports drug discovery programs aimed at developing treatments for pulmonary arterial hypertension, chronic kidney disease, and cancer.

Basic Information

Product Name	Sarafotoxin S6A1
CAS No.	119965-38-7
Molecular Formula	C124H186N34O37S5
Molecular Weight	~2850.3 g/mol
Synonyms	Sarafotoxin S6a; Sarafotoxin S6a (1-21); S6a Sarafotoxin; Sarafotoxin 6a; Sarafotoxin S6a Peptide; Endothelin-like peptide; SRTX-S6A; SRTX S6A; S6A Sarafotoxin
EINECS	Contact for details

Quality Control

Every batch of Sarafotoxin S6A1 is produced and analyzed under strict quality management protocols to ensure identity, purity, and biological activity. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. Certificates of Analysis (COA) detailing purity, HPLC profile, and mass spectrometry data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity	Verified by functional assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.