Description

Atrial Natriuretic Factor (5-23)Amide is a bioactive synthetic peptide fragment derived from the endogenous cardiac hormone. This compound is a critical research tool for studying cardiovascular physiology, renal function, and natriuretic peptide receptor (NPR) signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cardiovascular and metabolic disease research.

Application

• Biomedical Research: Used as a reference standard and active agent in studies investigating the mechanisms of atrial natriuretic peptide (ANP) in blood pressure regulation and sodium excretion.
• Receptor Binding Assays: Essential for competitive binding studies to characterize and quantify natriuretic peptide receptors (NPR-A, NPR-B, NPR-C).
• Signal Transduction Studies: Employed to activate guanylyl cyclase pathways and study downstream second messenger effects, such as cGMP production.
• In Vitro & Ex Vivo Models: Applied in cell culture and isolated tissue/organ preparations to assess vasodilation, diuresis, and natriuresis.
• Pharmaceutical Development: Serves as a key intermediate or pharmacological tool in the discovery and development of novel cardiovascular therapeutics.
• Diagnostic Kit Development: May be used in the calibration and development of immunoassays for detecting natriuretic peptides.

Basic Information

Product Name	Atrial Natriuretic Factor (5-23)Amide
CAS No.	119903-19-4
Molecular Formula	C85H134N26O24S2
Molecular Weight	1919.3 g/mol
Synonyms	ANF (5-23) amide; Atrial Natriuretic Peptide (5-23) amide; ANP (5-23) amide; hANP (5-23) amide; Cardionatrin (5-23) amide; Atriopeptin (5-23) amide; Ser103-Tyr126 ANP amide; H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-NH2 (Disulfide bridge: Cys7-Cys23)
EINECS	Contact for details

Quality Control

Our Atrial Natriuretic Factor (5-23)Amide is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing purity, peptide content, and solvent residues.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.