Description

2,2-Difluorobenzodioxole-4-Carboxaldehyde is a specialized fluorinated aromatic aldehyde building block of significant interest in advanced organic synthesis. Its unique structure, featuring a benzodioxole core and difluoro substitution, makes it a valuable precursor for constructing complex heterocyclic systems and fine chemicals. This high-purity intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluorobenzodioxole moiety can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Functional Material Research: Employed in the synthesis of monomers and polymers for advanced materials with specific optical or electronic properties.
• Organic Synthesis Building Block: Utilized in multi-step synthetic routes to construct complex heterocycles, such as benzofurans and dioxolanes, via its reactive aldehyde group.

Basic Information

Product Name	2,2-Difluorobenzodioxole-4-Carboxaldehyde
CAS No.	119895-68-0
Molecular Formula	C8H4F2O3
Molecular Weight	186.11 g/mol
Synonyms	4-Formyl-2,2-difluoro-1,3-benzodioxole; 2,2-Difluoro-1,3-benzodioxole-4-carboxaldehyde; 2,2-Difluoro-1,3-benzodioxole-4-carbaldehyde; 1,3-Benzodioxole-4-carboxaldehyde, 2,2-difluoro-; Difluorobenzodioxole Carboxaldehyde; 2,2-DFBD-Carboxaldehyde
EINECS	Contact for details

Quality Control

Our 2,2-Difluorobenzodioxole-4-Carboxaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere for long-term preservation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.