Description

(D-Proline, 3-Hydroxy-, (3R)- ) CAS NO 119677-21-3 is a high-purity, non-proteinogenic amino acid derivative characterized by its specific stereochemistry at the 3-position. This compound is a critical chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive molecules. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require enantiomerically pure components for drug discovery, peptide synthesis, and asymmetric catalysis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and other enzyme-targeted drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate modified proline residues, influencing peptide conformation and biological activity.
• Asymmetric Catalysis: Serves as a precursor or ligand for chiral catalysts and auxiliaries in stereoselective chemical transformations.
• Biochemical Research: Employed as a standard or reagent in metabolic pathway studies, enzyme-substrate interaction research, and as a tool compound.
• Agrochemical Development: Utilized in the research and synthesis of advanced, chiral agrochemicals with specific modes of action.
• Diagnostic Reagent Manufacturing: A component in the production of specialized reagents for clinical diagnostics and analytical assays.

Basic Information

Item	Details
Product Name	(D-Proline, 3-Hydroxy-, (3R)- ) CAS NO 119677-21-3
CAS No.	119677-21-3
Molecular Formula	C5H9NO3
Molecular Weight	131.13 g/mol
Synonyms	(3R)-3-Hydroxy-D-proline; D-3-Hydroxyproline; (R)-3-Hydroxypyrrolidine-2-carboxylic acid; (2R,3R)-3-Hydroxypyrrolidine-2-carboxylic acid; 3-Hydroxy-D-proline; Hydroxyproline, D-; 119677-21-3; D-3-Hyp
EINECS	Contact for details

Quality Control

Our (D-Proline, 3-Hydroxy-, (3R)- ) CAS NO 119677-21-3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed results from methods including HPLC, chiral analysis, and NMR. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.