Description

2'-o-Triflyl-2,3'-Anhydroxylosyluracil is a specialized nucleoside derivative and a key synthetic intermediate in advanced organic chemistry. This compound is valued for its role as a versatile building block in the synthesis of modified oligonucleotides and nucleoside analogs. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel antiviral agents, antisense oligonucleotides, and other therapeutic nucleic acid technologies.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used as a modified building block for creating antisense oligonucleotides and siRNA molecules with enhanced stability and specificity.
• Medicinal Chemistry Research: Serves as a key scaffold for structure-activity relationship (SAR) studies in drug discovery programs targeting viral polymerases.
• Bioconjugation Chemistry: The reactive triflyl group enables its use in selective conjugation reactions for labeling or attaching other functional molecules.
• Process Development: Employed in the scale-up and optimization of synthetic routes for complex nucleoside pharmaceuticals.

Basic Information

Product Name	2'-o-Triflyl-2,3'-Anhydroxylosyluracil
CAS No.	119637-71-7
Molecular Formula	C10H9F3N2O8S
Molecular Weight	374.25 g/mol
Synonyms	2'-O-Trifluoromethanesulfonyl-2,3'-anhydroxylosyluracil; 2,3'-Anhydro-2'-O-triflyluridine; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-((trifluoromethyl)sulfonyloxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2'-O-Triflyl-2,3'-anhydrouridine; Uridine, 2,3'-anhydro-2'-O-[(trifluoromethyl)sulfonyl]-; 2'-O-Trifluoromethanesulfonyl-2,3'-anhydrouridine
EINECS	Contact for details

Quality Control

Our 2'-o-Triflyl-2,3'-Anhydroxylosyluracil is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.