Description

Cholecystokinin (26-32), Tyr-Gly-Nle(28,31) Phenethyl Ester is a synthetic, biologically active peptide fragment derived from the C-terminal sequence of the cholecystokinin (CCK) hormone. This compound is a valuable research-grade biochemical tool, specifically engineered with norleucine (Nle) substitutions at positions 28 and 31 to enhance its metabolic stability and receptor binding affinity. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neurobiology, gastroenterology, and drug discovery programs targeting CCK receptors.

Application

• Neuroscience Research: As a potent and selective CCK receptor agonist/antagonist tool for studying the role of CCK in anxiety, satiety, nociception, and memory processes.
• Gastrointestinal Physiology Studies: For investigating CCK-mediated effects on pancreatic enzyme secretion, gallbladder contraction, and gut motility in experimental models.
• Drug Discovery & Development: Serving as a critical reference standard and pharmacological probe in high-throughput screening (HTS) assays to identify and characterize novel therapeutics targeting CCK pathways.
• Biochemical Assay Development: Used in the development and validation of receptor binding assays (RBA) and functional cellular assays to study G-protein coupled receptor (GPCR) signaling.
• Academic & Institutional Research: A key reagent for basic scientific research in university and government laboratories focusing on peptide hormone signaling and neuropeptide function.

Basic Information

Item	Details
Product Name	Cholecystokinin (26-32), Tyr-Gly-Nle(28,31) Phenethyl Ester
CAS No.	119400-92-9
Molecular Formula	C48H66N8O10S
Molecular Weight	947.15 g/mol
Synonyms	CCK (26-32), Nle(28,31)-CCK (26-32) Phenethyl Ester; Tyr-Gly-Nle-Asp-Tyr(SO3H)-Nle-Gly-Trp-Nle-Asp-Phenethylamide; CCK-8S Analog; Sincalide Analog; Cholecystokinin Octapeptide (26-33) Analog; CCK-8 (Nle28,31) Phenethyl Ester; A-71623 (research code)
EINECS	Contact for details

Quality Control

Our Cholecystokinin (26-32), Tyr-Gly-Nle(28,31) Phenethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results to ensure the material meets the stringent requirements for life science research. Our quality commitment aligns with the standards expected for research biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.