Description

7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid, 8-Amino-9-Fluoro-2,3-Dihydro-3-Methyl-10-(4-Methyl-1-Piperazinyl)-7-Oxo-, (3S)- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key chiral synthon in the synthesis of modern fluoroquinolone antibiotics, valued for its structural complexity and biological activity. It is essential for pharmaceutical R&D laboratories and API manufacturers targeting the development of next-generation antibacterial agents.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A critical chiral building block for the production of novel fluoroquinolone antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new antibacterial compounds.
• Process Chemistry & Scale-Up: Serves as a key intermediate in the optimization and commercial-scale manufacturing processes for antibiotic APIs.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory compliance in pharmaceutical production.
• Biochemical Research: Utilized in studies investigating the mechanism of action of topoisomerase inhibitors and bacterial DNA gyrase.

Basic Information

Item	Details
Product Name	7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid, 8-Amino-9-Fluoro-2,3-Dihydro-3-Methyl-10-(4-Methyl-1-Piperazinyl)-7-Oxo-, (3S)-
CAS No.	119354-43-7
Molecular Formula	C19H22FN5O4
Molecular Weight	403.41 g/mol
Synonyms	(3S)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid; Sitafloxacin Intermediate; (S)-Sitafloxacin Intermediate; DU-6859a Intermediate; Gracevit Intermediate; (3S)-8-Amino-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
EINECS	Contact for details

Quality Control

Our 7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid, 8-Amino-9-Fluoro-2,3-Dihydro-3-Methyl-10-(4-Methyl-1-Piperazinyl)-7-Oxo-, (3S)- is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical applications. Each batch is subjected to rigorous analytical testing, including chiral purity verification, to guarantee high chemical and isomeric purity. A comprehensive Certificate of Analysis (COA) detailing identity, assay, impurity profile, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (3S-isomer)
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.