Description

Glidobactin H CAS NO 119314-46-4 is a potent, naturally occurring cyclic depsipeptide antibiotic belonging to the glidobactin family. This compound is valued for its significant biological activity, particularly as a proteasome inhibitor, making it a critical tool in biochemical and pharmacological research. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies for investigating novel therapeutic pathways and studying cellular protein degradation mechanisms.

Application

• Biochemical Research: Used as a specific and potent inhibitor of the proteasome complex for studying ubiquitin-proteasome pathway dynamics.
• Pharmaceutical R&D: Serves as a lead compound or reference standard in the discovery and development of new anti-cancer and anti-inflammatory agents.
• Mechanism of Action Studies: Employed to elucidate the role of proteasomal degradation in various disease models, including oncology, neurology, and immunology.
• Cell Biology: A tool for inducing apoptosis and studying cell cycle regulation in cultured cell lines.
• Enzyme Inhibition Assays: Acts as a high-affinity ligand in assays designed to screen for or characterize other proteasome inhibitors.
• Academic Research: Fundamental research into natural product biosynthesis, structure-activity relationships (SAR), and microbial secondary metabolites.

Basic Information

Product Name	Glidobactin H
CAS No.	119314-46-4
Molecular Formula	C34H57N5O8
Molecular Weight	663.85 g/mol
Synonyms	Glidobactin H; Cystargolide H; Glidobactin H, from *Polyangium brachysporum*; Cyclo[(2S,3S)-3-hydroxy-2-methylpentanoyl-L-leucyl-D-leucyl-L-isoleucyl-D-seryl-(2S,3S)-3-amino-2-hydroxy-4-methylpentanoyl]; (3S,6S,9S,12S,15S,18S,21S,24S)-3,6,12,15-Tetraisobutyl-9-[(1S)-1-hydroxyethyl]-18-[(1R)-1-hydroxyethyl]-21-isopropyl-1,4,7,10,13,16,19,22-octaazacyclotetracosan-2,5,8,11,14,17,20,23-octone
EINECS	Contact for details

Quality Control

Our Glidobactin H is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity and potency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Due to its hygroscopic (moisture-sensitive) nature, the product should be handled under anhydrous conditions and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay	≥ 98% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.