Description

Tetanus Toxin (830-843) is a highly purified, defined fragment of the tetanus neurotoxin, a potent protein exotoxin produced by *Clostridium tetani*. This specific peptide sequence is critical for research into the molecular mechanisms of neurotoxicity, neuronal signaling, and receptor binding. It is an essential biological reagent for neuroscientists, toxicologists, and pharmaceutical developers working on vaccine development, antitoxin research, and neurological disorder models. The product is supplied with a documented CAS Registry Number for precise identification and regulatory compliance.

Application

• Neuroscience Research: Used as a precise tool to study synaptic vesicle release, neuronal uptake, and retrograde axonal transport mechanisms.
• Vaccine & Antitoxin Development: Serves as a key antigen or target for evaluating the efficacy of next-generation tetanus vaccines and therapeutic neutralizing antibodies.
• Molecular Toxicology: Employed in assays to investigate the structure-function relationship of clostridial neurotoxins and their interaction with neuronal membranes and receptors.
• Diagnostic Reagent Production: Acts as a calibrated standard or component in the development of highly sensitive immunoassays for tetanus toxin detection.
• Cell Biology Studies: Utilized to probe intracellular trafficking pathways and the effects of targeted proteolysis on neuronal proteins like VAMP/synaptobrevin.
• Pharmaceutical Screening: Provides a biologically relevant target for high-throughput screening of compound libraries seeking novel neurotoxin inhibitors.

Basic Information

Item	Detail
Product Name	Tetanus Toxin (830-843)
CAS No.	119260-99-0
Molecular Formula	C71H114N20O23S
Molecular Weight	1639.86 g/mol
Synonyms	Tetanus Toxin Fragment (830-843); Tetanus Neurotoxin (830-843); TeNT (830-843); Clostridium tetani Toxin Peptide 830-843; H-Cys-Asn-Thr-Pro-Leu-Thr-Glu-Ile-Lys-Gly-Asn-Asn-Tyr-Cys-OH; Cys-Asn-Thr-Pro-Leu-Thr-Glu-Ile-Lys-Gly-Asn-Asn-Tyr-Cys; CNTPLTEIKGNNYC (single-letter amino acid code)
EINECS	Contact for details

Quality Control

Every batch of Tetanus Toxin (830-843) is manufactured and analyzed under stringent quality systems. We ensure compliance with high-purity research-grade standards, with identity and purity verified by multiple orthogonal methods. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, peptide content, and analytical results. Our quality commitment supports reproducible and reliable outcomes in your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture absorption. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or aqueous buffers
Single-Letter Sequence	CNTPLTEIKGNNYC
Molecular Weight	1639.86 Da (average)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.