Description

Glidobactin E is a potent, naturally occurring cyclic depsipeptide antibiotic belonging to the glidobactin family. This compound is valued for its significant biological activity, particularly as a proteasome inhibitor, making it a critical tool in biochemical and pharmacological research. It is primarily utilized by research institutions and pharmaceutical companies engaged in the study of novel therapeutic pathways, cancer research, and the development of anti-infective agents.

Application

• Biochemical Research: Used as a specific and potent inhibitor of the proteasome complex to study protein degradation pathways and cellular regulation.
• Anticancer Agent Development: Investigated for its potential to induce apoptosis in cancer cell lines by inhibiting proteasome activity.
• Antimicrobial Studies: Serves as a reference compound in research exploring new antibiotics against resistant bacterial strains.
• Pharmacology & Mechanism of Action (MOA) Studies: Employed to elucidate the biological mechanisms and therapeutic potential of proteasome inhibitors.
• Standards & Controls: Used as a high-purity analytical standard or control material in quality control laboratories for method development and validation.

Basic Information

Product Name	Glidobactin E
CAS No.	119259-74-4
Molecular Formula	C34H57N5O8
Molecular Weight	663.85 g/mol
Synonyms	Glidobactin E; Glidobactin E (antibiotic); Cilastatin Impurity E; (3S,6R,9S,12R,15S,18S,21S,24S,27S,30S)-9-[(2S)-Butan-2-yl]-21-[(2R)-butan-2-yl]-6,15,24-triisobutyl-3,12,18,27-tetramethyl-1,4,7,10,13,16,19,22,25,28-decaoxa-2,5,8,11,14,17,20,23,26,29-decaazacyclotriacontane-30-carboxamide; Cyclic depsipeptide antibiotic.
EINECS	Contact for details

Quality Control

Every batch of Glidobactin E is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. Due to its hygroscopic nature, the product should be handled under anhydrous conditions and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.