Description

3-(2-Fluorobenzyl)-3,6-Dihydro-7H-[1,2,3]Triazolo[4,5-D]Pyrimidin-7-One is a high-purity, advanced pharmaceutical intermediate belonging to the fused triazolopyrimidinone class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting kinase inhibition and other therapeutic pathways. It is primarily required by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of investigational new drugs and potential APIs.
• Kinase Inhibitor Development: Serves as a core scaffold for creating potent and selective kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to improve drug-like properties.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale manufacturing of candidate compounds.
• Biochemical Tool Compound: May be utilized in the development of assay probes for high-throughput screening and target validation.
• Custom Synthesis: A starting material for the custom synthesis of more complex, proprietary molecules for client-specific R&D programs.

Basic Information

Product Name	3-(2-Fluorobenzyl)-3,6-Dihydro-7H-[1,2,3]Triazolo[4,5-D]Pyrimidin-7-One
CAS No.	119222-30-9
Molecular Formula	C12H10FN5O
Molecular Weight	259.24 g/mol
Synonyms	3-(2-Fluorobenzyl)-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one; 7H-[1,2,3]Triazolo[4,5-d]pyrimidin-7-one, 3-(2-fluorobenzyl)-3,6-dihydro-; 3-(2-Fluorobenzyl)-3,6-dihydro-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one; 119222-30-9; 3-(2-Fluorobenzyl)-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one; Fused triazolopyrimidinone derivative; 2-Fluorobenzyl triazolopyrimidinone
EINECS	Contact for details

Quality Control

Our 3-(2-Fluorobenzyl)-3,6-Dihydro-7H-[1,2,3]Triazolo[4,5-D]Pyrimidin-7-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.