Description

n-α-Carbobenzoxy-D-Allo-Threonine CAS NO 119221-16-8 is a protected amino acid derivative of significant importance in advanced organic synthesis. This compound serves as a crucial chiral building block for the construction of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, bioactive peptides, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled incorporation of the D-allo-threonine residue with N-terminal protection.
• Biochemical Research: Employed in academic and industrial laboratories for studying enzyme-substrate interactions, protein engineering, and structure-activity relationships (SAR).
• Fine Chemical Production: Serves as a starting material or intermediate in the synthesis of complex, high-value specialty chemicals and catalysts.
• Protecting Group Chemistry: The carbobenzoxy (Cbz) group facilitates selective reactions in multi-step synthetic pathways, which are later cleaved under specific conditions.

Basic Information

Product Name	n-α-Carbobenzoxy-D-Allo-Threonine
CAS No.	119221-16-8
Molecular Formula	C₁₅H₁₉NO₆
Molecular Weight	309.32 g/mol
Synonyms	N-Cbz-D-allo-threonine; Cbz-D-allo-Thr-OH; Z-D-allo-Thr-OH; Benzyloxycarbonyl-D-allo-threonine; (2R,3S)-2-[[(Benzyloxy)carbonyl]amino]-3-hydroxybutanoic acid; D-allo-Threonine, N-[(phenylmethoxy)carbonyl]-; N-[(Benzyloxy)carbonyl]-D-allo-threonine; N-Carbobenzoxy-D-allo-threonine
EINECS	Contact for details

Quality Control

Our n-α-Carbobenzoxy-D-Allo-Threonine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and fine chemical synthesis. Certificates of Analysis (COA) detailing specific batch results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.