Description

Dendrotoxin K is a highly selective and potent polypeptide neurotoxin derived from the venom of the Black Mamba snake (*Dendroaspis polylepis*). This compound is a critical research tool for the study of voltage-gated potassium (Kv) channels, specifically targeting Kv1.1 subtypes. It is essential for neuroscientists, pharmacologists, and toxicologists engaged in fundamental neurological research and drug discovery programs targeting channelopathies.

Application

• Neuroscience Research: Selective blockade of Kv1.1 potassium channels to study neuronal excitability, synaptic transmission, and action potential propagation.
• Pharmacology & Drug Discovery: Used as a reference standard and pharmacological tool in high-throughput screening (HTS) assays to identify novel modulators of potassium channels.
• Toxicology Studies: Investigation of venom mechanisms and the development of potential antivenoms or therapeutic countermeasures.
• Ion Channel Characterization: Essential for electrophysiology studies (e.g., patch-clamp) to characterize the biophysical and pharmacological properties of specific potassium channel subtypes.
• Biochemical Assays: Used in binding studies and competitive displacement assays to determine receptor affinity and specificity.

Basic Information

Product Name	Dendrotoxin K
CAS No.	119128-61-9
Molecular Formula	C184H281N55O53S7
Molecular Weight	4235.9 g/mol
Synonyms	Dendrotoxin K; DTX-K; Toxin K; Dendrotoxin I Homolog; Potassium Channel Toxin DTX-K; α-Dendrotoxin Homolog; ShK-like Toxin; Black Mamba Toxin K
EINECS	Contact for details

Quality Control

Our Dendrotoxin K is produced and purified under stringent conditions to ensure the highest levels of biological activity and purity, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, bioactivity, and sterility data. We adhere to ISO 9001 quality management standards, and our processes are designed to meet the rigorous demands of academic and pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Biological Activity (IC50 on Kv1.1)	≤ 1 nM
Endotoxin Level (LAL)	< 1.0 EU/µg
Moisture Content (KF)	≤ 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.