Description

Fmoc-L-Aspartic Acid CAS NO 119062-05-4 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound matters because it provides the crucial aspartic acid building block with an Fmoc-protecting group, enabling the controlled, sequential assembly of complex peptides. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research laboratories developing therapeutic peptides, peptide hormones, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the automated, sequential synthesis of custom peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide-based drugs, including anticancer agents and metabolic regulators.
• Bioconjugation & Protein Engineering: Serves as a modified amino acid precursor for site-specific labeling or functionalization of proteins.
• Combinatorial Chemistry Libraries: A key component in generating diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Biochemical Research: Employed in studies of protein structure-function relationships, enzyme substrates, and receptor ligands.
• Production of Aspartame Analogs: Used in research for synthesizing novel sweeteners or flavor-enhancing peptides.

Basic Information

Product Name	Fmoc-L-Aspartic Acid
CAS No.	119062-05-4
Molecular Formula	C19H17NO6
Molecular Weight	355.34 g/mol
Synonyms	Fmoc-Asp-OH; Fmoc-L-Asp-OH; N-(9-Fluorenylmethoxycarbonyl)-L-aspartic Acid; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]butanedioic acid; Fmoc-Aspartic Acid; N-Fmoc-L-aspartic acid; Fmoc-D-Aspartic Acid (enantiomer); Fmoc-Asp(OtBu)-OH (side-chain protected analog)
EINECS	Contact for details

Quality Control

Our Fmoc-L-Aspartic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with research and cGMP-grade standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent absorption of atmospheric moisture, which can affect purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.