Description

Angiotensin II Amide (1-7), Sar(1)- is a synthetic heptapeptide analog of angiotensin II, characterized by the substitution of sarcosine at position 1. This modification confers specific biological activity and stability, making it a valuable research-grade biochemical. It serves as a critical tool for investigating the renin-angiotensin system (RAS), cardiovascular physiology, and receptor-ligand interactions. This compound is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life science sectors.

Application

• Biomedical Research: A key reagent for studying the physiological and pathological roles of the renin-angiotensin system (RAS) in cardiovascular and renal function.
• Pharmacological Studies: Used in receptor binding assays and functional studies to characterize angiotensin receptor subtypes (e.g., AT1, AT2) and evaluate potential drug candidates.
• Peptide Chemistry Reference Standard: Serves as a high-purity reference material for analytical method development, validation, and quality control in peptide synthesis.
• Cell Signaling & Physiology: Employed in cell-based assays to investigate intracellular signaling pathways activated by angiotensin peptides.
• Academic & Institutional Research: Fundamental tool for university and research institute laboratories focused on hypertension, heart failure, and metabolic disorders.

Basic Information

Product Name	Angiotensin II Amide (1-7), Sar(1)-
CAS No.	118977-33-6
Molecular Formula	C₄₂H₆₂N₁₂O₁₁
Molecular Weight	910.99 g/mol
Synonyms	Sar¹-Angiotensin II (1-7); Sar¹-Ang II (1-7); [Sar¹]-Angiotensin II (1-7) amide; Asp-Arg-Val-Tyr-Ile-His-Sar; Sarcosin¹-angiotensin II (1-7); Angiotensin (1-7) Sar¹ analog; H-Asp-Arg-Val-Tyr-Ile-His-Sar-OH
EINECS	Contact for details

Quality Control

Our Angiotensin II Amide (1-7), Sar(1)- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality system is designed to meet the stringent requirements of scientific and pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in water, acetic acid; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.