Description

Fmoc-D-Allo-Ile-Oh CAS NO 118904-37-3 is a protected, non-proteinogenic amino acid derivative used in solid-phase peptide synthesis (SPPS). This compound is essential for introducing the D-allo-isoleucine residue into peptide chains, enabling the creation of peptides with specific stereochemistry and enhanced metabolic stability. It is a critical building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, stepwise construction of custom peptide sequences.
• Pharmaceutical Research: Used in the development and production of peptide-based drugs, including hormone analogs and antimicrobial peptides.
• Peptidomimetic Design: Incorporation into synthetic peptide analogs to improve bioavailability, stability, and target specificity.
• Bioconjugation: Serves as a precursor for creating peptide tags and linkers used in antibody-drug conjugates (ADCs) and diagnostic probes.
• Chemical Biology Studies: Utilized to probe protein structure-function relationships and enzyme-substrate interactions.
• Academic & Industrial R&D: A fundamental reagent in laboratories focused on organic synthesis, medicinal chemistry, and peptide science.

Basic Information

Product Name	Fmoc-D-Allo-Ile-Oh
CAS No.	118904-37-3
Molecular Formula	C₂₁H₂₃NO₄
Molecular Weight	353.41 g/mol
Synonyms	Fmoc-D-allo-isoleucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-allo-isoleucine; (2R,3S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-methylpentanoic acid; Fmoc-D-aIle-OH; FMOC-D-ALLO-ISOLEUCINE; Fmoc-D-allo-Ile; N-Fmoc-D-allo-isoleucine
EINECS	Contact for details

Quality Control

Our Fmoc-D-Allo-Ile-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurities are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.