Description

Urodilatin (Human) is a natriuretic peptide hormone, a 32-amino acid polypeptide with the CAS registry number 118812-69-4. This compound is of significant interest for its potent biological activity in regulating renal and cardiovascular function, primarily through natriuresis, diuresis, and vasodilation. It is a critical research-grade biochemical for pharmaceutical R&D, particularly in the study of heart failure, hypertension, and renal physiology, serving academic institutions, biotech firms, and contract research organizations globally.

Application

• Pharmaceutical Research & Development: A key reference standard and active ingredient in preclinical studies for novel cardiovascular and renal therapeutics.
• Biochemical Assay Development: Used as a calibrant and control in the development of immunoassays (e.g., ELISA) to detect natriuretic peptides.
• Mechanistic Studies: Essential for in vitro and in vivo research into the physiological pathways of sodium and water balance, blood pressure regulation, and heart-kidney crosstalk.
• Cell Signaling Research: Investigates the activation of particulate guanylyl cyclase receptors (NPR-A) and subsequent intracellular cGMP pathways.
• Drug Discovery Screening: Serves as a target compound in high-throughput screening campaigns to identify agonists or antagonists of the natriuretic peptide receptor.
• Academic & Clinical Research: Supports fundamental research in universities and hospitals exploring biomarkers and therapeutic targets for congestive heart failure and acute kidney injury.

Basic Information

Product Name	Urodilatin (Human)
CAS No.	118812-69-4
Molecular Formula	C149H244N50O45S4
Molecular Weight	3506.1 g/mol
Synonyms	Urodilatin; ANP-(95-126); Atriopeptin (95-126); hANP (95-126); URO; Renal Natriuretic Peptide; CDD/ANP-95-126; Auriculin B (95-126)
EINECS	Contact for details

Quality Control

Our Urodilatin (Human) is produced and tested under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We adhere to rigorous internal quality protocols to guarantee batch-to-batch consistency and reliability for your critical research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by mass spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity	Determined by in vitro assay (cGMP accumulation or receptor binding)
Endotoxin Level	< 1.0 EU/µg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.