Description

Atrial Natriuretic Peptide (4-24), Frog is a specific, biologically active fragment of the frog-derived natriuretic peptide hormone. This high-purity peptide is critical for cardiovascular and renal research, serving as a precise tool for studying natriuretic peptide receptors and signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on endocrinology, hypertension, and heart failure research.

Application

• Biomedical Research: A key reagent for investigating the structure, function, and signaling mechanisms of natriuretic peptide receptors (NPR-A, NPR-B, NPR-C).
• Pharmacological Studies: Used in competitive binding assays and functional bioassays to screen and characterize novel therapeutic compounds targeting cardiovascular diseases.
• Endocrinology Research: Essential for studying the physiological roles of natriuretic peptides in blood pressure regulation, sodium excretion, and fluid homeostasis.
• Comparative Physiology: Serves as a model peptide for evolutionary studies of the natriuretic peptide system across different species.
• In Vitro Diagnostics Development: Can be employed as a reference standard or calibrator in the development of immunoassays for related biomarkers.
• Signal Transduction Analysis: Used to activate guanylyl cyclase pathways in cell culture models to study downstream cellular effects.

Basic Information

Product Name	Atrial Natriuretic Peptide (4-24), Frog
CAS No.	118691-44-4
Molecular Formula	C108H172N34O31S2
Molecular Weight	2475.9 g/mol
Synonyms	ANP (4-24), Frog; Atriopeptin (4-24), Frog; Cardionatrin (4-24), Frog; rANP (4-24); Frog Atrial Natriuretic Factor Fragment 4-24; H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-OH (Disulfide bridge); 118691-44-4
EINECS	Contact for details

Quality Control

Our Atrial Natriuretic Peptide (4-24), Frog is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all critical quality attributes to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.