Description

Parathyroid Hormone-Related Protein(3-34) CAS NO 118689-25-1 is a specific bioactive fragment of the parathyroid hormone-related protein (PTHrP), a critical regulator of calcium homeostasis and bone metabolism. This high-purity peptide is essential for advanced biochemical research and pharmaceutical development, particularly in studies of bone biology and calcium signaling pathways. It serves as a vital tool for researchers in academia, pharmaceutical R&D, and biotechnology focusing on metabolic bone diseases, cancer biology, and endocrine disorders.

Application

• Biochemical Research: Used as a specific antagonist to study PTH/PTHrP receptor (PTH1R) signaling and calcium ion transport mechanisms.
• Pharmaceutical Development: Serves as a reference standard and key intermediate in the development of therapeutics for osteoporosis, hypercalcemia of malignancy, and other bone-related disorders.
• Cell Biology Studies: Applied in in vitro assays to investigate the role of PTHrP in cell proliferation, differentiation, and apoptosis.
• Endocrinology: A critical reagent for exploring the endocrine and paracrine functions of PTHrP in calcium and phosphate homeostasis.
• Diagnostic Kit Manufacturing: Utilized as a calibrated antigen or control in immunoassays designed to measure PTHrP levels in clinical samples.
• Academic & Institutional Research: Supports fundamental research in physiology, pharmacology, and molecular biology related to bone and mineral metabolism.

Basic Information

Product Name	Parathyroid Hormone-Related Protein(3-34)
CAS No.	118689-25-1
Molecular Formula	C164H267N51O48
Molecular Weight	3695.2 g/mol
Synonyms	PTHrP (3-34); Parathyroid Hormone-Related Peptide (3-34); PTH-Related Protein Fragment (3-34); hPTHrP(3-34) amide; PTHrP 3-34 amide; [Tyr34]PTHrP(3-34)NH2; PTHrP Antagonist (3-34); Parathyroid hormone-like protein (3-34)
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone-Related Protein(3-34) is manufactured under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee traceability, consistency, and compliance with research-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the lyophilized powder desiccated. Avoid repeated freeze-thaw cycles of reconstituted solutions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Biological Activity	Assessed by receptor binding assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.