Description

Cholecystokinin (26-33), I-Tyr-Gly-Nle(28,31)- CAS NO 118688-24-7 is a synthetic, biologically active peptide fragment derived from the C-terminal octapeptide of the gastrointestinal hormone cholecystokinin (CCK). This modified analog is engineered for enhanced stability and specificity in research applications, making it a critical tool for studying CCK receptor interactions and signaling pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neurogastroenterology, appetite regulation, and peptide-based drug discovery.

Application

• Neuroscience Research: Investigation of CCK's role in anxiety, satiety, nociception, and memory processes.
• Gastrointestinal Physiology Studies: Used as a selective agonist to study pancreatic enzyme secretion, gallbladder contraction, and gut motility.
• Receptor Binding Assays: A high-affinity ligand for characterizing and quantifying CCK1 (CCK-A) and CCK2 (CCK-B) receptor subtypes.
• Drug Discovery & Development: Serves as a reference standard and lead compound for developing novel therapeutics targeting metabolic disorders and CNS conditions.
• Biochemical Tool: Employed in cell-based assays and signal transduction studies to elucidate G-protein coupled receptor (GPCR) mechanisms.

Basic Information

Product Name	Cholecystokinin (26-33), I-Tyr-Gly-Nle(28,31)-
CAS No.	118688-24-7
Molecular Formula	C49H65N9O11S
Molecular Weight	988.2 g/mol
Synonyms	CCK-8 (sulfated), I-Tyr-Gly-Nle(28,31)-CCK-26-33; Cholecystokinin Octapeptide, sulfated; Sincalide analog; CCK-26-33, I-Tyr-Gly-Nle(28,31)-; Asp-Tyr(SO3H)-Met-Gly-Trp-Nle-Asp-Nle-NH2; CCK-8s analog; Nle28,31-CCK(26-33); CCK fragment 26-33 amide
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Each batch of Cholecystokinin (26-33), I-Tyr-Gly-Nle(28,31)- undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results for your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.