Description

Cholecystokinin (26-33), I-Tyr-Gly-(Nle(28,31),4-No2-Phe(33)) is a synthetic, biologically active peptide fragment of the cholecystokinin hormone, designed for high receptor affinity and stability. This compound is critical for advanced research in neurobiology and gastroenterology, serving as a potent and selective agonist for CCK receptors. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers for investigating central nervous system functions, digestive processes, and developing novel therapeutic agents.

Application

• Neuroscience Research: As a potent CCK receptor agonist for studying anxiety, satiety, pain modulation, and dopamine-related behaviors in preclinical models.
• Gastrointestinal Physiology Studies: For investigating pancreatic enzyme secretion, gallbladder contraction, and gut motility in experimental settings.
• Drug Discovery & Development: A key reference standard and pharmacological tool in screening assays and lead optimization for CNS and metabolic disorders.
• Biochemical Assay Development: Used in the development and validation of receptor binding assays (RBA) and functional cellular assays (e.g., calcium flux).
• Academic & Clinical Research: Fundamental research into the role of CCK in memory, learning, and neuropsychiatric conditions.
• Diagnostic Reagent Manufacturing: Potential use as a component in specialized diagnostic kits for research purposes.

Basic Information

Item	Detail
Product Name	Cholecystokinin (26-33), I-Tyr-Gly-(Nle(28,31),4-No2-Phe(33))
CAS No.	118643-58-6
Molecular Formula	C52H68N12O13S
Molecular Weight	1101.23 g/mol
Synonyms	CCK-8 (sulfated), Sincalide; CCK (26-33), sulfated; Cholecystokinin Octapeptide (CCK-8); SQ 19,844; CCK-8S; Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 (modified analog); [Nle28,31,4-NO2-Phe33]-CCK(26-33)
EINECS	Contact for details

Quality Control

Our Cholecystokinin (26-33) analog is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, peptide content, and solvent residues. Our quality commitment ensures material suitable for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.