Description

Fmoc-Gln-Oh CAS NO 118609-68-0 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). It serves as a critical building block for the controlled incorporation of glutamine into peptide chains, enabling the research and production of complex bioactive peptides and proteins. This compound is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on developing novel therapeutics, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected glutamine derivative, it is a fundamental reagent for the stepwise construction of custom peptide sequences.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide-based drugs, including hormones, enzyme inhibitors, and targeted therapeutics.
• Bioconjugation and Protein Engineering: Facilitates the site-specific modification of peptides and proteins for creating antibody-drug conjugates (ADCs) or labeled biomolecules.
• Combinatorial Chemistry Libraries: A key component in generating diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Biochemical Research: Employed in studies of protein structure-function relationships, signal transduction pathways, and molecular recognition events.
• Production of Glutamine-Containing Peptide Fragments: Essential for synthesizing specific peptide segments used in fragment condensation or native chemical ligation strategies.

Basic Information

Item	Details
Product Name	Fmoc-Gln-Oh
CAS No.	118609-68-0
Molecular Formula	C₂₀H₂₀N₂O₅
Molecular Weight	368.38 g/mol
Synonyms	Fmoc-L-glutamine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamine; Fmoc-Glutamine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-aminopentanoic acid; Fmoc-Gln-OH; Nα-Fmoc-L-glutamine; Fmoc-L-Gln-OH; N-Fmoc-L-glutamic acid 5-amide
EINECS	Contact for details

Quality Control

Our Fmoc-Gln-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, chiral analysis to confirm enantiomeric integrity, and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.