Description

Fmoc-L-Lys(Dansyl)-OH is a specialized, dual-labeled amino acid derivative designed for advanced peptide synthesis and biochemical research. This compound is critical for researchers requiring precise fluorescence detection and monitoring during solid-phase peptide synthesis (SPPS) and related applications. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on developing peptide-based therapeutics, diagnostic probes, and fluorescence-based assays.

Application

• Solid-Phase Peptide Synthesis (SPPS): Used as a fluorescently tagged, Fmoc-protected building block for the controlled incorporation of a lysine residue with a dansyl fluorophore.
• Bioconjugation & Probe Development: Serves as a key intermediate for creating fluorescently labeled peptides, proteins, and other biomolecules for tracking and imaging studies.
• FRET (Förster Resonance Energy Transfer) Studies: The dansyl group acts as a donor or acceptor in FRET pairs for investigating molecular interactions and conformational changes.
• Peptide-Based Diagnostic Reagents: Enables the development of sensitive fluorescent probes and assay components for diagnostic applications.
• Biochemical Research: Facilitates studies in enzyme kinetics, receptor-ligand binding, and intracellular trafficking using fluorescence microscopy or spectroscopy.
• Quality Control Reference Standard: Employed as a high-purity reference material in analytical laboratories for method development and validation.

Basic Information

Item	Detail
Product Name	Fmoc-L-Lys(Dansyl)-OH
CAS No.	118584-90-0
Molecular Formula	C36H39N3O7S
Molecular Weight	657.78 g/mol
Synonyms	Fmoc-Lys(Dansyl)-OH; Nε-Dansyl-Nα-Fmoc-L-lysine; Fmoc-Lys(Dns)-OH; Nα-(9-Fluorenylmethoxycarbonyl)-Nε-(5-dimethylaminonaphthalene-1-sulfonyl)-L-lysine; Fmoc-Lys(Dnp)-OH (common alternate); Fmoc-D-Lys(Dansyl)-OH (enantiomer); N-Fmoc-N'-dansyl-L-lysine; (2S)-6-[[5-(Dimethylamino)naphthalen-1-yl]sulfonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-L-Lys(Dansyl)-OH is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We adhere to cGMP principles for production and control, ensuring reliability for critical pharmaceutical and biotech development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.