Description

5,8,10-Trideaza-5,6,7,8-Tetrahydropteroylornithine is a specialized folate analog and a key intermediate in the synthesis of novel antifolate compounds. This compound matters for its critical role in advanced pharmaceutical research, particularly in the development of targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in oncology, antimicrobial drug discovery, and metabolic pathway studies.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel antifolate drugs targeting dihydrofolate reductase (DHFR).
• Oncology Research: Used in the development and study of chemotherapeutic agents designed to inhibit cancer cell proliferation.
• Antimicrobial Agent Development: Applied in research for creating new antibiotics and antiparasitic drugs that disrupt folate metabolism in pathogens.
• Biochemical Research: Utilized as a tool compound to study folate-dependent enzymatic pathways and cellular metabolism.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Item	Detail
Product Name	5,8,10-Trideaza-5,6,7,8-Tetrahydropteroylornithine
CAS No.	118537-34-1
Molecular Formula	C₁₄H₂₀N₆O₄
Molecular Weight	336.35 g/mol
Synonyms	5,8,10-Trideazapteroylornithine; DDATHF-Ornithine; (6R)-5,8,10-Trideaza-5,6,7,8-tetrahydropteroylornithine; Lometrexol Ornithine Analog; Antifolate Intermediate; NSC 687719; PT523 Precursor
EINECS	Contact for details

Quality Control

Our 5,8,10-Trideaza-5,6,7,8-Tetrahydropteroylornithine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.