Description

Myelin Basic Protein (87-99) (Human, Bovine, Rat) CAS NO 118506-26-6 is a defined peptide fragment corresponding to residues 87-99 of the myelin basic protein, available in species-specific human, bovine, and rat sequences. This peptide is a critical research tool for studying the immunopathogenesis of demyelinating diseases, particularly multiple sclerosis (MS), as it contains a major encephalitogenic epitope. It is primarily utilized by neuroscience researchers, immunologists, and pharmaceutical developers engaged in autoimmune disease research, epitope mapping, and the development of novel therapeutic and diagnostic strategies.

Application

• Autoimmune Disease Research: Key antigen for inducing and studying Experimental Autoimmune Encephalomyelitis (EAE), the primary animal model for multiple sclerosis.
• Immunological Assays: Used as a coating or target antigen in ELISA, ELISPOT, and T-cell proliferation assays to measure immune responses.
• Epitope Mapping & Characterization: Serves as a standard for defining the specificity of autoreactive T-cells and antibodies in neuroinflammatory conditions.
• Drug Discovery & Screening: Employed in high-throughput screening platforms to identify potential therapeutic compounds that modulate the immune response to MBP.
• Vaccine Development: Investigated in the research and development of tolerogenic vaccines aimed at treating or preventing autoimmune demyelination.
• Biomarker Studies: Used in studies to correlate immune reactivity against specific MBP epitopes with disease activity and progression in patients.

Basic Information

Product Name	Myelin Basic Protein (87-99) (Human, Bovine, Rat)
CAS No.	118506-26-6
Molecular Formula	C62H103N19O21 (Human sequence)
Molecular Weight	~1390.6 g/mol (Human sequence)
Synonyms	MBP (87-99); Myelin Basic Protein Peptide (87-99); Encephalitogenic Peptide MBP87-99; Antigen MBP87-99; MBP Peptide Fragment 87-99; Acetyl-Ala-Ser-Gln-Lys-Arg-Pro-Ser-Gln-Arg-His-Gly-Ser-Lys-NH2 (Human); Ac-ASQKRPSQRHGSA-NH2
EINECS	Contact for details

Quality Control

Our Myelin Basic Protein (87-99) peptides are manufactured and analyzed under stringent conditions to ensure high purity, correct sequence, and batch-to-batch consistency, which are critical for reproducible research outcomes. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, amino acid analysis, and mass spectrometry data. We adhere to quality management principles suitable for research and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the lyophilized powder at -20°C or below. This product is hygroscopic (moisture-sensitive). Solutions should be prepared in appropriate buffers (e.g., sterile PBS) and stored as aliquots at -20°C to -80°C to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (HPLC)	≥ 95%
Identification (Mass Spec)	Consistent with theoretical molecular weight
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 70% (by weight)
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.