Description

(+)-cis-(2R,3S)-3-Hydroxyproline CAS NO 118492-86-7 is a high-purity, non-proteinogenic amino acid derivative characterized by its specific stereochemistry at the 2 and 3 positions. This compound is a critical chiral building block and intermediate in the synthesis of complex bioactive molecules, particularly in pharmaceutical research and development. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications such as peptide synthesis and drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially protease inhibitors and other therapeutic peptides.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce conformational constraints or specific hydroxyl functionality into peptide chains.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies and metabolic pathway research involving proline and hydroxyproline metabolism.
• Glycopeptide & Antibiotic Synthesis: An important precursor in the synthesis of complex natural products like glycopeptide antibiotics.
• Cosmetic & Dermatological Actives: Potential use in the development of advanced skincare formulations targeting collagen synthesis and skin repair.
• Asymmetric Catalysis: Employed as a chiral ligand or auxiliary in asymmetric synthesis to induce stereoselectivity.

Basic Information

Product Name	(+)-cis-(2R,3S)-3-Hydroxyproline
CAS No.	118492-86-7
Molecular Formula	C5H9NO3
Molecular Weight	131.13 g/mol
Synonyms	(2R,3S)-3-Hydroxypyrrolidine-2-carboxylic acid; cis-3-Hydroxy-D-proline; (2R,3S)-3-Hydroxyproline; L-cis-3-Hydroxyproline (obsolete); 3(R)-Hydroxy-D-proline; (2R,3S)-3-Hydroxy-2-pyrrolidinecarboxylic acid; Hydroxyproline isomer
EINECS	Contact for details

Quality Control

Our (+)-cis-(2R,3S)-3-Hydroxyproline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.