Description

Fmoc-D-Orn(Boc)-Oh CAS NO 118476-89-4 is a high-purity, orthogonally protected derivative of the non-proteinogenic amino acid D-ornithine, specifically engineered for solid-phase peptide synthesis (SPPS). Its value lies in enabling the precise, racemization-free incorporation of D-ornithine into complex peptide sequences, which is critical for developing peptides with enhanced metabolic stability and novel biological activities. This building block is essential for research and development scientists in the pharmaceutical, biotechnology, and life science sectors focused on peptide-based drug discovery, diagnostic agents, and biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of complex peptides and peptidomimetics.
• Pharmaceutical R&D: Used in the research and development of novel therapeutic peptides, including antimicrobial peptides (AMPs), hormone analogs, and targeted drug conjugates.
• Bioconjugation and Probe Development: Serves as a precursor for introducing functional handles (via the side-chain) for labeling peptides with fluorophores, biotin, or other probes.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify new bioactive peptide leads.
• Academic Research: Fundamental tool in biochemistry and molecular biology studies investigating protein-protein interactions, enzyme substrates, and receptor ligands.
• Production of Custom Peptides: Critical raw material for CROs and CDMOs offering custom peptide synthesis services for clients worldwide.

Basic Information

Product Name	Fmoc-D-Orn(Boc)-Oh
CAS No.	118476-89-4
Molecular Formula	C₂₆H₃₂N₂O₆
Molecular Weight	468.55 g/mol
Synonyms	Fmoc-D-ornithine(Boc)-OH; N-α-Fmoc-N-δ-Boc-D-ornithine; (2R)-5-{[(2-Methylpropan-2-yl)oxy]carbonyl}amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid; Fmoc-D-Orn(Boc)-OH; Boc-D-Orn(Fmoc)-OH; N-δ-Boc-N-α-Fmoc-D-ornithine; D-Orn(Fmoc,Boc)-OH; N-Fmoc-N'-Boc-D-ornithine
EINECS	Contact for details

Quality Control

Our Fmoc-D-Orn(Boc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to meet exacting research and cGMP starting material standards. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.