Description

Fmoc-L-Ser(β-D-Glcac4)-Oh is a sophisticated, protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise glycosylation in synthetic peptides, enabling the study of glycoprotein structure and function. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic institutions focused on developing novel glycopeptide therapeutics and diagnostic tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled introduction of O-linked β-D-glucosamine (GlcNAc) moieties onto serine residues.
• Glycopeptide & Glycoprotein Research: For the chemical synthesis of homogeneous glycopeptide models to study glycosylation effects on protein folding, stability, and biological activity.
• Pharmaceutical Development: In the research and production of novel glycopeptide-based drugs, including potential antimicrobials, vaccines, and targeted cancer therapies.
• Bioconjugation & Chemical Biology: Serves as a valuable intermediate for creating chemically defined probes to investigate carbohydrate-protein interactions and cell signaling pathways.
• Process Development: Used in scaling up the synthesis of complex therapeutic peptides requiring site-specific glycosylation for improved pharmacokinetic properties.

Basic Information

Product Name	Fmoc-L-Ser(β-D-Glcac4)-Oh
CAS No.	118358-38-6
Molecular Formula	C30H36N2O10
Molecular Weight	584.62 g/mol
Synonyms	Fmoc-Ser(β-D-GlcNAc(Ac)3)-OH; N-α-Fmoc-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-L-serine; Fmoc-L-Serine, O-[2-(acetylamino)-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosyl]-; Fmoc-Ser(Ac3-β-D-GlcNAc)-OH; Fmoc-O-(2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-L-serine; Fmoc-L-Ser[β-D-GlcNAc(Ac)3]-OH; Fmoc-Ser(GlcNAc(Ac)3)-OH; Glycosylated Fmoc-Serine derivative
EINECS	Contact for details

Quality Control

Our Fmoc-L-Ser(β-D-Glcac4)-Oh is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry best practices for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.