Description

Echistatin CAS NO 118337-11-4 is a potent and highly specific disintegrin peptide originally isolated from the venom of the saw-scaled viper, *Echis carinatus*. This compound is a critical research tool for studying cell adhesion and signaling pathways, as it selectively inhibits the integrin αIIbβ3 (GPIIb/IIIa) and αvβ3 receptors. It is primarily utilized by researchers in the fields of cardiovascular biology, oncology, and cell biology to investigate platelet aggregation, angiogenesis, and tumor metastasis. Its high specificity makes it an invaluable reagent for in vitro and in vivo studies requiring precise modulation of integrin-mediated processes.

Application

• Biomedical Research: Used as a selective antagonist to study the role of αIIbβ3 and αvβ3 integrins in cellular processes.
• Cardiovascular Studies: Applied in research models to investigate mechanisms of platelet aggregation and thrombosis.
• Cancer Research: Employed to examine tumor cell adhesion, migration, and angiogenesis in various cancer models.
• Cell Biology Assays: Utilized in in vitro assays to dissect integrin-mediated signaling pathways and cytoskeletal reorganization.
• Drug Discovery: Serves as a reference compound and pharmacological tool in the development of novel anti-thrombotic and anti-cancer therapeutics.
• Biochemical Characterization: Acts as a ligand in studies to characterize integrin receptor affinity and specificity.

Basic Information

Product Name	Echistatin
CAS No.	118337-11-4
Molecular Formula	C184H282N56O55S7
Molecular Weight	~ 5400 g/mol
Synonyms	Echistatin (Viper venom peptide); Echistatin α; Disintegrin Echistatin; RGD-containing peptide Echistatin; Platelet aggregation inhibitor peptide; GPIIb-IIIa antagonist; αIIbβ3 integrin inhibitor; αvβ3 integrin inhibitor
EINECS	Contact for details

Quality Control

Our Echistatin is produced and tested to meet the stringent requirements of life science research. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and biological activity. Certificates of Analysis (COA) are provided, detailing results from HPLC for purity assessment, mass spectrometry for identity confirmation, and functional activity assays. We adhere to rigorous quality management protocols to guarantee batch-to-batch consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (IC50)	Specified per batch (typically in nM range for αIIbβ3 inhibition)
Endotoxin Level	< 1.0 EU/mg
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.