Description

Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-Methylketone Trifluoroacetate Salt is a specialized, high-purity synthetic peptide derivative used as a potent and selective inhibitor of proteolytic enzymes. This compound is critical for biochemical research and pharmaceutical development, offering precise control over enzymatic activity in complex biological systems. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on protease mechanism studies, drug discovery, and the development of therapeutic agents.

Application

• Protease Inhibition Studies: Serves as a key biochemical tool for investigating the function and mechanism of specific proteases, particularly cathepsins and related cysteine proteases.
• Pharmaceutical R&D: Used in high-throughput screening and lead optimization for developing novel therapeutic agents targeting protease-related diseases such as osteoporosis, arthritis, and cancer metastasis.
• Biochemical Assay Development: Acts as a standard or reference inhibitor in the development and validation of enzymatic activity assays.
• Cell Biology Research: Employed to modulate intracellular protease activity to study apoptosis (programmed cell death), protein turnover, and other cellular processes.
• Structural Biology: Used in co-crystallization studies to determine the three-dimensional structure of protease-inhibitor complexes via X-ray crystallography.
• Diagnostic Reagent Formulation: A potential component in the formulation of specialized diagnostic kits for measuring specific protease activity in clinical samples.

Basic Information

Product Name	Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-Methylketone Trifluoroacetate Salt
CAS No.	118253-05-7
Molecular Formula	C34H44F3N3O8
Molecular Weight	703.73 g/mol
Synonyms	Z-FK-2,4,6-TMB-CMK TFA Salt; Z-Phe-Lys-CH2OCO-(2,4,6-Trimethylbenzene) TFA Salt; Benzyloxycarbonyl-Phenylalanyl-Lysyl-(2,4,6-Trimethylbenzoyloxy)methanone Trifluoroacetate; Cathepsin B Inhibitor IV (Z-FK-CMK); Protease Inhibitor Z-FK-CMK; (Benzyloxycarbonyl)-L-phenylalanyl-N-[(benzyloxy)carbonyl]-L-lysyl-(2,4,6-trimethylbenzoyloxy)methanone trifluoroacetate; Z-Phe-Lys-CH2OCO-Mes TFA Salt
EINECS	Contact for details

Quality Control

Our Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-Methylketone Trifluoroacetate Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with research-grade standards and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity (Assay)	IC50 provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.