Description

Bradykinin, Phe(8)-Psi-Ch2Nh-Arg(9)- is a potent, modified peptide analog of the endogenous vasoactive peptide bradykinin, designed with a reduced peptide bond (Psi-CH2NH) to enhance metabolic stability and receptor selectivity. This compound is critical for advanced research in cardiovascular physiology, neurobiology, and inflammation, serving as a highly specific pharmacological tool and a potential lead structure for therapeutic development. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on kinin receptor signaling pathways, pain research, and drug discovery programs.

Application

• Pharmacological Research: Used as a selective B1 or B2 bradykinin receptor agonist/antagonist (depending on the specific analog) to study receptor function, signal transduction, and downstream effects in cellular and animal models.
• Cardiovascular Studies: Investigates the role of the kallikrein-kinin system in blood pressure regulation, vascular permeability, and endothelial function.
• Inflammation and Pain Research: A key tool for modeling inflammatory responses, neurogenic inflammation, and chronic pain conditions to evaluate novel analgesic compounds.
• Drug Discovery & Development: Serves as a reference standard and a structural template for designing new peptide-based therapeutics with improved stability and potency.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening (HTS) assays, ELISA, and radioimmunoassays (RIA) targeting the kinin system.
• Academic & Clinical Research: Supports fundamental studies in physiology and pathology related to sepsis, asthma, arthritis, and diabetic complications.

Basic Information

Item	Detail
Product Name	Bradykinin, Phe(8)-Psi-Ch2Nh-Arg(9)-
CAS No.	118122-39-7
Molecular Formula	C50H73N15O11
Molecular Weight	1052.2 g/mol
Synonyms	Bradykinin, [Phe8ψ(CH2NH)Arg9]-; [Phe8ψ(CH2NH)Arg9]-Bradykinin; Reduced Peptide Bond Bradykinin Analog; B1/B2 Bradykinin Receptor Modulator; H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Pheψ[CH2NH]Arg-OH; Bradykinin Analog (Phe8-psi-CH2NH-Arg9); BK (Phe8-psi-CH2NH-Arg9)
EINECS	Contact for details

Quality Control

Every batch of Bradykinin, Phe(8)-Psi-Ch2Nh-Arg(9)- is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for critical research applications. Certificates of Analysis (COA) detailing purity by HPLC, peptide content, and related substance profiles are available for each lot. Our quality commitment aligns with the standards expected for research-grade biochemicals, supporting reproducibility in scientific studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.