Description

(D-Trp12,Tyr34)-Pth (7-34) Amide (Bovine) is a synthetic, biologically active peptide fragment derived from bovine parathyroid hormone. This compound serves as a critical research tool for studying calcium metabolism, bone physiology, and the structure-activity relationships of PTH and its receptors. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on metabolic disorders and endocrine research.

Application

• Biomedical Research: Used as a reference standard and probe in studies of parathyroid hormone (PTH) receptor binding and signal transduction pathways.
• Drug Discovery: Serves as a key intermediate or analog in the development of novel therapeutics for osteoporosis, hyperparathyroidism, and other bone-related diseases.
• Biochemical Assays: Employed in competitive binding assays (e.g., ELISA, RIA) to measure PTH activity or screen for receptor antagonists/agonists.
• Structure-Activity Relationship (SAR) Studies: Essential for mapping the functional domains of PTH to understand the role of specific amino acid substitutions (D-Trp12, Tyr34).
• Academic & Clinical Research: Supports fundamental research into calcium and phosphate homeostasis, renal function, and bone remodeling processes.

Basic Information

Product Name	(D-Trp12,Tyr34)-Pth (7-34) Amide (Bovine)
CAS No.	118102-98-0
Molecular Formula	C₁₄₈H₂₂₀N₄₄O₄₀
Molecular Weight	~3270.6 g/mol
Synonyms	[D-Trp12,Tyr34]-bPTH(7-34) amide; Parathyroid Hormone (7-34) amide, bovine [D-Trp12,Tyr34]-; bPTH(7-34) amide, [D-Trp12,Tyr34]-; [D-Tryptophan12, Tyrosine34]-PTH (7-34) amide (bovine); PTH (7-34) fragment, bovine, modified; PTH receptor antagonist analog; (D-Trp12, Tyr34) PTH(7-34)NH2
EINECS	Contact for details

Quality Control

Our (D-Trp12,Tyr34)-Pth (7-34) Amide (Bovine) is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. All batches are supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to cGMP guidelines for peptide synthesis, and our quality system is designed to meet the rigorous standards of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store the lyophilized powder under desiccant. Avoid repeated freeze-thaw cycles of reconstituted solutions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.