Description

Fmoc-Thr(Bzl)-Oh CAS NO 117872-75-0 is a protected amino acid derivative, specifically an Fmoc-protected threonine with a benzyl (Bzl) side-chain protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptide sequences. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for peptide-based drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the Fmoc-strategy synthesis of therapeutic and research peptides.
• Peptide Drug Intermediate: For the production of active pharmaceutical ingredients (APIs) in peptide-based medicines.
• Bioconjugation and Labeling: Used to introduce threonine residues with a protected hydroxyl group for subsequent chemical modification.
• Combinatorial Chemistry Libraries: Serves as a building block for creating diverse peptide libraries for high-throughput screening.
• Academic and Industrial Research: Fundamental reagent for studying protein structure-function relationships and developing novel biomaterials.
• Custom Peptide Service Providers: A standard inventory item for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-Thr(Bzl)-Oh
CAS No.	117872-75-0
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-O-tert-butyl-threonine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-benzyl-L-threonine; Fmoc-Thr(Bzl)-OH; Fmoc-L-threonine(Bzl)-OH; (2S,3R)-3-(Benzyloxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid; N-Fmoc-O-benzyl-L-threonine; Fmoc-Thr(OBzl)-OH; L-Threonine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, O-benzyl ether
EINECS	Contact for details

Quality Control

Our Fmoc-Thr(Bzl)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We support compliance with cGMP, ISO, and other relevant quality standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.