Description

Pam3-Cys-Ala-Gly-Oh CAS NO 117858-54-5 is a synthetic lipopeptide derivative, specifically a toll-like receptor 2 (TLR2) agonist. This compound is a critical research tool and a key component in the development of novel vaccine adjuvants and immunotherapies. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on immunology, vaccine development, and cancer research.

Application

• Vaccine Adjuvant Research: Used as a potent immunostimulant to enhance the efficacy of experimental vaccines.
• Immunology Studies: A key reagent for studying TLR2-mediated signaling pathways and innate immune responses.
• Cancer Immunotherapy: Investigated as a component in therapeutic vaccines designed to stimulate anti-tumor immunity.
• Infectious Disease Research: Employed in the development of adjuvants for vaccines against bacterial and viral pathogens.
• Peptide-Based Drug Development: Serves as a model compound or active pharmaceutical ingredient (API) in preclinical studies for novel immunomodulators.
• Cell Culture & In Vitro Assays: Used to activate immune cells like macrophages and dendritic cells in experimental settings.

Basic Information

Product Name	Pam3-Cys-Ala-Gly-Oh
CAS No.	117858-54-5
Molecular Formula	C52H98N8O10S
Molecular Weight	1027.45 g/mol
Synonyms	Pam3CAG; N-Palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-L-cysteinyl-L-alanylglycine; Pam3Cys-Ala-Gly-OH; Tripalmitoyl-S-glyceryl cysteinylalanylglycine; TLR2 Agonist Pam3Cys; S-[2,3-Bis(palmitoyloxy)propyl]-N-palmitoylcysteinylalanylglycine; (R)-N-((S)-1-((S)-2-Acetamido-3-mercaptopropylamino)-1-oxo-3-(palmitoyloxy)propan-2-yl)tetradecanamide
EINECS	Contact for details

Quality Control

Our Pam3-Cys-Ala-Gly-Oh is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and endotoxins, to ensure it meets the stringent requirements of pharmaceutical and biological research. Certificates of Analysis (COA) with full traceability are provided.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Endotoxin Level	< 10 EU/mg
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.