Description

Boc-Ala-Met-Oh is a protected dipeptide building block, specifically N-(tert-Butoxycarbonyl)-L-alanyl-L-methionine, widely used in solid-phase peptide synthesis (SPPS). Its primary value lies in providing a controlled method for elongating peptide chains, where the Boc (tert-butoxycarbonyl) group offers orthogonal protection that can be selectively removed under acidic conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and biochemical tools. Its reliable quality is critical for ensuring high coupling efficiency and final peptide purity.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of complex therapeutic peptides and peptidomimetics.
• Solid-Phase Peptide Synthesis (SPPS): Used in Boc-chemistry SPPS protocols for the sequential addition of amino acids.
• Biochemical Research: Employed in academic and industrial R&D for studying peptide structure, function, and interactions.
• Combinatorial Chemistry: A valuable component in libraries for drug discovery and high-throughput screening.
• API Development: Serves as an intermediate in the production of Active Pharmaceutical Ingredients (APIs) for peptide-based drugs.
• Proteomics & Diagnostics: Used in the preparation of labeled peptides, antigens, or standards for diagnostic assays.

Basic Information

Product Name	Boc-Ala-Met-Oh
CAS No.	117823-40-2
Molecular Formula	C₁₄H₂₆N₂O₅S
Molecular Weight	334.43 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-alanyl-L-methionine; Boc-L-alanyl-L-methionine; Boc-Ala-Met-OH; (2S)-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]-4-methylsulfanylbutanoic acid; N-Boc-L-alanyl-L-methionine; Boc-Ala-Met; tert-Butoxycarbonylalanylmethionine
EINECS	Contact for details

Quality Control

Our Boc-Ala-Met-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-40.0° to -44.0° (c=1 in AcOH)
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.