Description

n-(3-Iodo-4-Azidophenylpropionamido)-S-(2-Thiopyridyl)Cysteine is a specialized, heterobifunctional crosslinking reagent designed for advanced bioconjugation and protein labeling applications. Its core value lies in its unique dual-reactive structure, featuring a photoactivatable azide group and a thiol-reactive pyridyl disulfide moiety, enabling controlled, sequential coupling strategies. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay creation who require precise and stable protein modifications.

Application

• Site-Specific Protein Conjugation: For attaching fluorophores, drugs, or other molecules to specific cysteine residues on antibodies and other therapeutic proteins.
• Surface Immobilization of Biomolecules: Used to create functionalized surfaces for biosensors, microarrays, and affinity chromatography resins.
• Photoaffinity Labeling: The aryl azide group allows for covalent crosslinking to target proteins upon UV irradiation, useful for studying protein-protein interactions.
• Bioconjugation in Drug Delivery Systems: Facilitating the development of antibody-drug conjugates (ADCs) and other targeted therapeutic constructs.
• Chemical Biology Probes: Serves as a key building block for synthesizing activity-based probes to study enzyme function and localization.
• Stable Intermediate Synthesis: Used in the multi-step synthesis of more complex bioconjugation reagents and molecular tools.

Basic Information

Product Name	n-(3-Iodo-4-Azidophenylpropionamido)-S-(2-Thiopyridyl)Cysteine
CAS No.	117820-47-0
Molecular Formula	C₁₇H₁₅IN₆O₃S₂
Molecular Weight	566.37 g/mol
Synonyms	3-Iodo-4-azido-N-[2-[[(2-pyridinyldithio)ethyl]amino]-2-oxoethyl]benzamide; S-(2-Pyridyldithio)cysteine derivative with 3-iodo-4-azidobenzoylpropionic acid; Heterobifunctional Crosslinker (Azide/Pyridyl Disulfide); Photoactivatable and Thiol-Reactive Crosslinker; 4-Azido-3-iodobenzoylpropionamido-S-(2-thiopyridyl)cysteine; N-[3-(3-Iodo-4-azidophenyl)propanoyl]-S-(2-pyridyldithio)cysteamine; Azido-PDP-Cysteine Derivative
EINECS	Contact for details

Quality Control

Our production of n-(3-Iodo-4-Azidophenylpropionamido)-S-(2-Thiopyridyl)Cysteine adheres to stringent quality protocols suitable for research and development applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant in a freezer dedicated for chemicals. This compound is both light-sensitive (store away from light) and hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term stability, store under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.