Description

Vasoactive Intestinal Peptide, Ac-(Lys(12,14)-Nle(17)-Val(26)-Thr(28))- is a synthetic, acetylated analog of the naturally occurring vasoactive intestinal peptide (VIP), engineered for enhanced stability and biological activity. This modified peptide is critical for advanced research and development in neuroendocrinology and immunology due to its potent receptor binding and signaling properties. It serves as a key biochemical tool for pharmaceutical companies and research institutions investigating inflammatory pathways, neuroprotection, and cellular communication.

Application

• Biomedical Research: Used as a high-purity reference standard and active agent in studies of VIP receptor (VPAC1/VPAC2) signaling, neuroendocrine function, and immune modulation.
• Drug Discovery & Development: Serves as a lead compound or pharmacological tool for developing novel therapeutics targeting conditions like inflammatory bowel disease (IBD), septic shock, and neurodegenerative disorders.
• In Vitro Diagnostics: Employed in the development and calibration of immunoassays (ELISA, RIA) to detect and quantify VIP-related biomarkers in clinical samples.
• Cell Culture & Physiology Studies: Applied in cell-based assays to study its effects on smooth muscle relaxation, vasodilation, and secretion of hormones like prolactin and growth hormone.
• Peptide Chemistry & Conjugation: Acts as a substrate for further chemical modification, labeling (e.g., with fluorophores or biotin), or conjugation due to its specific lysine residues.

Basic Information

Product Name	Vasoactive Intestinal Peptide, Ac-(Lys(12,14)-Nle(17)-Val(26)-Thr(28))-
CAS No.	117811-28-6
Molecular Formula	C147H238N42O43S
Molecular Weight	3327.8 g/mol
Synonyms	Ac-[Lys12,14, Nle17, Val26, Thr28]-VIP; Acetylated VIP Analog; [Acetyl-Lys12,14, Nle17, Val26, Thr28]-Vasoactive Intestinal Peptide; Modified VIP; VIP (1-28), human, rat, Ac-[Lys12,14, Nle17, Val26, Thr28]-; Stabilized VIP Analog; VPAC Receptor Agonist Analog
EINECS	Contact for details

Quality Control

Every batch of Vasoactive Intestinal Peptide, Ac-(Lys(12,14)-Nle(17)-Val(26)-Thr(28))- is manufactured and analyzed under strict quality systems. We employ advanced chromatographic (HPLC, UPLC) and spectroscopic (MS) techniques to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, peptide content, and impurity profiles, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.