Description

Enkephalin-Leu Methyl Ester, Ala(2)-Cyclopropyl-Phe(4)- is a synthetic, modified peptide analog of the endogenous opioid peptide enkephalin. This compound is of significant value for advanced biochemical and pharmacological research, particularly in the study of opioid receptor interactions and structure-activity relationships (SAR). It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience, pain management, and novel therapeutic discovery.

Application

• Neuroscience Research: Used as a specialized tool compound for investigating the function and binding mechanisms of opioid receptors (delta and mu subtypes).
• Structure-Activity Relationship (SAR) Studies: The cyclopropyl modification at the phenylalanine residue makes it a critical analog for probing the steric and electronic requirements of receptor binding pockets.
• Biochemical Assay Development: Serves as a reference standard or competitive ligand in receptor binding assays, fluorescence polarization (FP) assays, and other in vitro screening platforms.
• Peptide Chemistry & Drug Discovery: Acts as a key intermediate or template for the design and synthesis of novel peptide-based therapeutics with potential analgesic properties.
• Metabolic Stability Studies: The methyl ester modification is often utilized to assess the stability and degradation pathways of peptide leads.

Basic Information

Product Name	Enkephalin-Leu Methyl Ester, Ala(2)-Cyclopropyl-Phe(4)-
CAS No.	117783-82-1
Molecular Formula	C33H44N6O7
Molecular Weight	636.74 g/mol
Synonyms	[D-Ala2, (4-Cyclopropyl)Phe4]-Leu-Enkephalin Methyl Ester; H-Tyr-D-Ala-Gly-(4-Cyclopropyl)Phe-Leu-OMe; Cyclopropyl-Phe4-Leu-Enkephalin Methyl Ester; (4-Cyclopropyl)Phe4,Leu5-Enkephalin Methyl Ester; [D-Ala2, (4-Cyclopropyl)Phe4, Leu5]-Enkephalin Methyl Ester; Opioid Peptide Analog 117783-82-1; Modified Leu-Enkephalin Methyl Ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity (by HPLC), peptide content, and identity confirmation. We adhere to GMP principles for handling high-value research biochemicals to guarantee batch-to-batch consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.