Description

(R)-9-Fluoro-3-Methyl-7-Oxo-10-(Piperazin-1-Yl)-2,3-Dihydro-7H-[1,4]Oxazino[2,3,4-Ij]Quinoline-6-Carboxylic Acid Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial importance as a key chiral building block in the synthesis of novel antibacterial agents, particularly fluoroquinolone derivatives. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers for the development and production of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and synthesis of novel, potent antibacterial fluoroquinolone drugs.
• Antibacterial Drug Development: Serves as a core structural component in the creation of new antibiotics targeting resistant bacterial strains.
• Organic Synthesis Research: Used in academic and industrial research to explore new chemical entities and structure-activity relationships (SAR) in medicinal chemistry.
• GMP Manufacturing: Supplied as a qualified starting material or intermediate for cGMP-compliant production processes of active pharmaceutical ingredients (APIs).
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	(R)-9-Fluoro-3-Methyl-7-Oxo-10-(Piperazin-1-Yl)-2,3-Dihydro-7H-[1,4]Oxazino[2,3,4-Ij]Quinoline-6-Carboxylic Acid Hydrochloride
CAS No.	117707-39-8
Molecular Formula	C20H21FN4O5 · HCl
Molecular Weight	452.87 g/mol (Free base: 416.41 g/mol)
Synonyms	(R)-Ofloxacin Intermediate; (R)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hydrochloride; (R)-Ofloxacin Hydrochloride; (R)-(-)-Ofloxacin Hydrochloride; Levofloxacin Related Compound; (3R)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride; (R)-DR-3355 Hydrochloride
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, documenting identity, purity, chiral purity, and impurity profiles. We support customer audits and can supply material manufactured under GMP-like conditions for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R-isomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.