Description

Parathyroid Hormone-Related Protein(3-40), Tyr(40)- CAS NO 117628-15-6 is a synthetic peptide fragment corresponding to a specific region of the Parathyroid Hormone-Related Protein (PTHrP). This high-purity peptide is a critical research tool for studying calcium metabolism, bone biology, and the role of PTHrP in various physiological and pathological processes. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers working in endocrinology, oncology, and metabolic disease research.

Application

• Biomedical Research: Used as a reference standard and active agent in studies investigating PTHrP signaling pathways, receptor binding, and biological activity.
• Assay Development: Serves as a critical calibrant and control in the development and validation of immunoassays (ELISA, RIA) for PTHrP detection.
• Drug Discovery: Employed in high-throughput screening (HTS) campaigns to identify and characterize novel agonists or antagonists targeting the PTH/PTHrP receptor.
• Cell Culture Studies: Applied in *in vitro* models to study the effects of PTHrP on osteoblast/osteoclast activity, chondrocyte function, and cellular proliferation.
• Metabolic Studies: Utilized in research focused on disorders of calcium homeostasis, such as hypercalcemia of malignancy.
• Antibody Production: Acts as a key immunogen for generating specific polyclonal or monoclonal antibodies against PTHrP.

Basic Information

Product Name	Parathyroid Hormone-Related Protein(3-40), Tyr(40)- CAS NO 117628-15-6
CAS No.	117628-15-6
Molecular Formula	C185H303N55O53S
Molecular Weight	4251.8 g/mol
Synonyms	PTHrP (3-40), Tyr(40)-; Parathyroid Hormone-like Protein (3-40); PTHLH (3-40); PTH-Related Protein Fragment (3-40); [Tyr40]PTHrP(3-40); Human PTHrP(3-40) amide; Hypercalcemia of malignancy factor fragment.
EINECS	Contact for details

Quality Control

Every batch of Parathyroid Hormone-Related Protein(3-40), Tyr(40)- is manufactured and tested under stringent quality management systems. Our products undergo rigorous analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure compliance with research-grade specifications. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.