Description

Bradykinin, Leu-Ile-Ser- is a synthetic peptide fragment derived from the endogenous kinin system, specifically representing a key sequence of the bradykinin molecule. This compound is of significant interest for its role in biochemical research and pharmaceutical development, particularly in studying inflammation, pain pathways, and cardiovascular regulation. It is primarily utilized by researchers in the life sciences, pharmaceutical R&D, and biotechnology sectors for use as a reference standard, a biochemical tool, and in the development of diagnostic assays.

Application

• Biochemical Research: Used as a critical reference standard and tool peptide for studying the bradykinin B2 receptor signaling pathways, inflammation, and pain mechanisms.
• Pharmaceutical Development: Serves as a key intermediate or reference compound in the research and development of novel anti-inflammatory drugs, analgesics, and cardiovascular therapeutics.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA) and other analytical methods designed to detect and quantify bradykinin-related peptides in biological samples.
• Cell Biology Studies: Applied in in vitro cell culture experiments to investigate cellular responses, such as calcium mobilization, nitric oxide release, and vascular permeability.
• Enzyme Substrate/Inhibitor Studies: Utilized in studies focusing on kininase enzymes (e.g., ACE, carboxypeptidase N) to understand peptide metabolism and degradation kinetics.

Basic Information

Product Name	Bradykinin, Leu-Ile-Ser-
CAS No.	117525-89-0
Molecular Formula	C35H59N11O9
Molecular Weight	777.92 g/mol
Synonyms	Bradykinin (5-7); Leu-Ile-Ser-Bradykinin fragment; H-Leu-Ile-Ser-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH; Bradykinin potentiator peptide fragment; Kinin fragment; L-I-S Bradykinin; BK (5-7) fragment
EINECS	Contact for details

Quality Control

Our Bradykinin, Leu-Ile-Ser- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and residual solvent levels are provided to ensure compliance with research-grade standards and support your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.