Description

Endothelin-1 (Human, Porcine) is a potent 21-amino acid vasoconstrictor peptide, a key isoform of the endothelin family. It is a critical research tool for studying cardiovascular physiology, vascular biology, and the pathophysiology of diseases like hypertension and pulmonary arterial hypertension. This high-purity peptide is essential for researchers and developers in pharmaceutical R&D, academic research, and biotechnology focusing on endothelin receptor antagonists and related therapeutic areas.

Application

• Biomedical Research: Fundamental studies on vasoconstriction, blood pressure regulation, and endothelial cell function.
• Drug Discovery & Development: A key standard and tool compound for screening and validating new endothelin receptor antagonists (ERAs).
• Cardiovascular Disease Models: Used to induce hypertension and vascular remodeling in preclinical animal models for pharmacological testing.
• Cell Signaling Studies: Investigating G-protein coupled receptor (GPCR) pathways, specifically ETA and ETB receptor activation and downstream effects.
• Diagnostic Assay Development: Serving as a reference standard in immunoassays (ELISA, RIA) for endothelin-1 quantification.
• Academic & Institutional Laboratories: For teaching and advanced research in physiology, pharmacology, and molecular biology.

Basic Information

Item	Details
Product Name	Endothelin-1 (Human, Porcine)
CAS No.	117399-94-7
Molecular Formula	C109H159N25O32S5
Molecular Weight	2492.0 g/mol (approximate)
Synonyms	ET-1; Endothelin 1; Big Endothelin-1 (39-21); Human Endothelin-1; Porcine Endothelin-1; Endothelin-1, human; Endothelin-1, porcine; L-Endothelin-1
EINECS	Contact for details

Quality Control

Our Endothelin-1 (Human, Porcine) is produced under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or under an inert atmosphere. Allow the vial to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Biological Activity	Determined by functional assay (e.g., receptor binding)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.