Description

N-(9-Fluorenylmethoxycarbonyl)-L-Alanine is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled and efficient assembly of complex peptide chains. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of therapeutic peptides, diagnostic agents, and novel biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the sequential construction of custom peptides.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Combinatorial Chemistry: A key reagent in the generation of diverse peptide libraries for high-throughput screening.
• Bioconjugation: Employed to introduce alanine residues or specific functional handles into proteins and other biomolecules.
• Academic Research: Essential for biochemical and structural biology studies involving peptide models and protein fragments.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of research-grade and GMP peptides.

Basic Information

Item	Details
Product Name	N-(9-Fluorenylmethoxycarbonyl)-L-Alanine
CAS No.	117398-49-9
Molecular Formula	C18H17NO4
Molecular Weight	311.33 g/mol
Synonyms	Fmoc-L-Alanine; Fmoc-Ala-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]propanoic acid; Fmoc-L-Ala; Fmoc-Alanine; N-Fmoc-L-alanine; L-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our N-(9-Fluorenylmethoxycarbonyl)-L-Alanine is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive synthetic applications. Each batch is tested via HPLC, NMR, and optical rotation analysis to confirm identity, purity, and enantiomeric integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.